Details of the Target

General Information of Target

Target ID LDTP04197
Target Name Serpin B4 (SERPINB4)
Gene Name SERPINB4
Gene ID 6318
Synonyms
PI11; SCCA2; Serpin B4; Leupin; Peptidase inhibitor 11; PI-11; Squamous cell carcinoma antigen 2; SCCA-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNSLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQISKVLHFD
QVTENTTEKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYQFLQEYL
DAIKKFYQTSVESTDFANAPEESRKKINSWVESQTNEKIKNLFPDGTIGNDTTLVLVNAI
YFKGQWENKFKKENTKEEKFWPNKNTYKSVQMMRQYNSFNFALLEDVQAKVLEIPYKGKD
LSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETCVDLHLPRFKMEESYDLKDTLR
TMGMVNIFNGDADLSGMTWSHGLSVSKVLHKAFVEVTEEGVEAAAATAVVVVELSSPSTN
EEFCCNHPFLFFIRQNKTNSILFYGRFSSP
Target Bioclass
Other
Family
Serpin family, Ov-serpin subfamily
Subcellular location
Cytoplasm
Function May act as a protease inhibitor to modulate the host immune response against tumor cells.
Uniprot ID
P48594
Ensemble ID
ENST00000341074.10
HGNC ID
HGNC:10570

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C279(1.12)  LDD3325  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 42-MG-BA C279(1.85)  LDD2244  [1]
 LDCM0023  KB03 A431 C279(1.07)  LDD2675  [1]
 LDCM0024  KB05 UACC257 C279(1.12)  LDD3325  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840