Details of the Target

General Information of Target

Target ID LDTP04146
Target Name Lymphotactin (XCL1)
Gene Name XCL1
Gene ID 6375
Synonyms
LTN; SCYC1; Lymphotactin; ATAC; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; SCM-1-alpha; Small-inducible cytokine C1; XC chemokine ligand 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLLILALLGICSLTAYIVEGVGSEVSDKRTCVSLTTQRLPVSRIKTYTITEGSLRAVIF
ITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG
Target Bioclass
Cytokine and receptor
Family
Intercrine gamma family
Subcellular location
Secreted
Function
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
Uniprot ID
P47992
Ensemble ID
ENST00000367818.4
HGNC ID
HGNC:10645

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C69(10.63)  LDD1705  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0024  KB05 T cell C69(10.63)  LDD1705  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Cytokine and receptor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet factor 4 (PF4) Intercrine alpha (chemokine CxC) family P02776
Platelet factor 4 variant (PF4V1) Intercrine alpha (chemokine CxC) family P10720
Stromal cell-derived factor 1 (CXCL12) Intercrine alpha (chemokine CxC) family P48061
C-C motif chemokine 13 (CCL13) Intercrine beta (chemokine CC) family Q99616
C-C motif chemokine 26 (CCL26) Intercrine beta (chemokine CC) family Q9Y258
C-C motif chemokine 5 (CCL5) Intercrine beta (chemokine CC) family P13501

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.