Details of the Target

General Information of Target

Target ID LDTP04139
Target Name Homeobox protein CDX-1 (CDX1)
Gene Name CDX1
Gene ID 1044
Synonyms
Homeobox protein CDX-1; Caudal-type homeobox protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYVGYVLDKDSPVYPGPARPASLGLGPQAYGPPAPPPAPPQYPDFSSYSHVEPAPAPPTA
WGAPFPAPKDDWAAAYGPGPAAPAASPASLAFGPPPDFSPVPAPPGPGPGLLAQPLGGPG
TPSSPGAQRPTPYEWMRRSVAAGGGGGSGKTRTKDKYRVVYTDHQRLELEKEFHYSRYIT
IRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQPPQPPMAHDITATPAGPSL
GGLCPSNTSLLATSSPMPVKEEFLP
Target Bioclass
Transcription factor
Family
Caudal homeobox family
Subcellular location
Nucleus
Function
Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.
Uniprot ID
P47902
Ensemble ID
ENST00000231656.13
HGNC ID
HGNC:1805

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LS180 Deletion: p.G242AfsTer18 .
NCIH2286 SNV: p.D70Y; p.Y133Ter .
PF382 SNV: p.Y133H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264