Details of the Target

General Information of Target

Target ID LDTP04138
Target Name Vasopressin V1b receptor (AVPR1B)
Gene Name AVPR1B
Gene ID 553
Synonyms
AVPR3; VPR3; Vasopressin V1b receptor; V1bR; AVPR V1b; AVPR V3; Antidiuretic hormone receptor 1b; Vasopressin V3 receptor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLG
QLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFA
STYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQG
SGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVG
GGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSV
QMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQ
PRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAE
TIIF
Target Type
Successful
Target Bioclass
GPCR
Family
G-protein coupled receptor 1 family, Vasopressin/oxytocin receptor subfamily
Subcellular location
Cell membrane
Function
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.; (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, may recognize and internalize the complex formed by AVP/Arg-vasopressin, SARS-CoV-2 spike protein and secreted ACE2 through DNM2/dynamin 2-dependent endocytosis.
TTD ID
T59881
Uniprot ID
P47901
DrugMap ID
TTL9MHW
Ensemble ID
ENST00000367126.5
HGNC ID
HGNC:896
ChEMBL ID
CHEMBL1921

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0223  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0223  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vasopressin Protein/peptide DB00067
Atosiban Small molecular drug DB09059
Desmopressin Small molecular drug D0U7SH
Lypressin Small molecular drug DB14642
Mozavaptan Small molecular drug D0F4NS
Oxytocin Small molecular drug D0M3FJ
Terlipressin Small molecular drug DB02638
Phase 4
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Atosiban Small molecular drug D0D8XY
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ssr149415 Small molecular drug D0SY9B
Abt-436 . D0RC0J
Investigative
Click To Hide/Show 37 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
D(Ch2)5[Tyr(Me)2]Avp Small molecular drug D0M4QM
D[Leu4,Dab8]Vp Small molecular drug D06SDG
D[Leu4,Dap8]Vp Small molecular drug D0O5TK
D[Pen1,Tyr(Me)2]Avp Small molecular drug D04JXX
Ym 218 Small molecular drug D00SGZ
Ym 471 Small molecular drug D00NIT
[3h]Nelivaptan Small molecular drug D01CSM
[Val4]Avp Small molecular drug D02YBV
Argenine Vasopressin . D01FDW
D[Arg4,Dab8]Vp . D0UK0O
D[Arg4,Lys8]Vp . D04MMD
D[Arg4,Orn8]Vp . D03BVC
D[Arg4]Avp . D0R7QC
D[Cha4,Dab8]Vp . D0HI2N
D[Cha4,Dap8]Vp . D09XWA
D[Cha4,Lys8]Vp . D05BHL
D[Cha4,Orn8]Vp . D05RNF
D[Cha4]Avp . D09RIE
D[D-3-pal2]Avp . D09OML
D[Leu4,Lys8]Vp . D03DXK
D[Leu4,Orn8]Vp . D0V3FF
D[Leu4]Avp . D0A6FK
D[Lys8(5/6-flu)]Vt . D0M3BJ
D[Orn4,Lys8]Vp . D0O8OF
D[Orn4,Orn8]Vp . D0YJ6C
D[Orn4]Avp . D0ZD0W
D[Orn8(5/6c-flu)]Vt . D02VVG
D[Thr4,Lys8(5/6c-flu)]Vt . D05YHE
D[Thr4,Orn8(5/6c-flu)]Vt . D0C8XX
D[Val4]Avp . D0W3IQ
Ph-284 . DB05452
Sr 121463 . DB05455
[Ho1][Lys8(5/6c-flu)]Vt . D0K0JJ
[Ho1][Orn8(5/6c-flu)]Vt . D09BWP
[Ho1][Thr4,Lys8(5/6c-flu)]Vt . D0Y5FO
[Ho1][Thr4,Orn8(5/6c-flu)]Vt . D0O6WN
[Lys8(Alexa 488) ]Pva . D0L0RP

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.