Details of the Target

General Information of Target

Target ID LDTP04137
Target Name P2Y purinoceptor 1 (P2RY1)
Gene Name P2RY1
Gene ID 5028
Synonyms
P2Y purinoceptor 1; P2Y1; ADP receptor; Purinergic receptor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYIL
VFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFG
DAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVV
VAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLI
VRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFND
RVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLN
ILPEFKQNGDTSL
Target Type
Literature-reported
Target Bioclass
GPCR
Family
G-protein coupled receptor 1 family
Subcellular location
Cell membrane
Function
Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation.
TTD ID
T67818
Uniprot ID
P47900
DrugMap ID
TTA93TL
Ensemble ID
ENST00000305097.6
HGNC ID
HGNC:8539
ChEMBL ID
CHEMBL4315

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C318(1.08)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C318(1.08)  LDD1507  [1]
 LDCM0276  AC17 HEK-293T C318(0.74)  LDD1515  [1]
 LDCM0285  AC25 HEK-293T C318(0.93)  LDD1524  [1]
 LDCM0294  AC33 HEK-293T C318(0.87)  LDD1533  [1]
 LDCM0303  AC41 HEK-293T C318(0.99)  LDD1542  [1]
 LDCM0311  AC49 HEK-293T C318(1.15)  LDD1550  [1]
 LDCM0320  AC57 HEK-293T C318(1.54)  LDD1559  [1]
 LDCM0356  AKOS034007680 HEK-293T C318(1.13)  LDD1570  [1]
 LDCM0404  CL17 HEK-293T C318(1.17)  LDD1608  [1]
 LDCM0417  CL29 HEK-293T C318(0.77)  LDD1621  [1]
 LDCM0431  CL41 HEK-293T C318(1.03)  LDD1635  [1]
 LDCM0440  CL5 HEK-293T C318(1.04)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C318(1.99)  LDD1647  [1]
 LDCM0457  CL65 HEK-293T C318(1.05)  LDD1660  [1]
 LDCM0470  CL77 HEK-293T C318(1.09)  LDD1673  [1]
 LDCM0483  CL89 HEK-293T C318(1.21)  LDD1686  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402