Details of the Target

General Information of Target

Target ID LDTP04118
Target Name 3-hydroxyanthranilate 3,4-dioxygenase (HAAO)
Gene Name HAAO
Gene ID 23498
Synonyms
3-hydroxyanthranilate 3,4-dioxygenase; EC 1.13.11.6; 3-hydroxyanthranilate oxygenase; 3-HAO; h3HAO; 3-hydroxyanthranilic acid dioxygenase; HAD
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MERRLGVRAWVKENRGSFQPPVCNKLMHQEQLKVMFIGGPNTRKDYHIEEGEEVFYQLEG
DMVLRVLEQGKHRDVVIRQGEIFLLPARVPHSPQRFANTVGLVVERRRLETELDGLRYYV
GDTMDVLFEKWFYCKDLGTQLAPIIQEFFSSEQYRTGKPIPDQLLKEPPFPLSTRSIMEP
MSLDAWLDSHHRELQAGTPLSLFGDTYETQVIAYGQGSSEGLRQNVDVWLWQLEGSSVVT
MGGRRLSLAPDDSLLVLAGTSYAWERTQGSVALSVTQDPACKKPLG
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
3-HAO family
Subcellular location
Cytoplasm, cytosol
Function Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. {|HAMAP-Rule:MF_03019}.
TTD ID
T46527
Uniprot ID
P46952
DrugMap ID
TTWON83
Ensemble ID
ENST00000294973.11
HGNC ID
HGNC:4796
ChEMBL ID
CHEMBL3108657

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JHH1 SNV: p.L137F DBIA    Probe Info 
KATOIII SNV: p.G235D .
MCC13 Substitution: p.P159L .
OZ Deletion: p.R266QfsTer10 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C23(1.27)  LDD3333  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0367  CL1 HEK-293T C23(1.00)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C23(0.82)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C23(0.87)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C23(1.11)  LDD1582  [2]
 LDCM0383  CL113 HEK-293T C23(1.26)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C23(1.21)  LDD1591  [2]
 LDCM0392  CL121 HEK-293T C23(1.04)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C23(1.25)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C23(0.92)  LDD1604  [2]
 LDCM0413  CL25 HEK-293T C23(0.81)  LDD1617  [2]
 LDCM0426  CL37 HEK-293T C23(0.96)  LDD1630  [2]
 LDCM0439  CL49 HEK-293T C23(0.86)  LDD1643  [2]
 LDCM0453  CL61 HEK-293T C23(1.01)  LDD1656  [2]
 LDCM0466  CL73 HEK-293T C23(1.06)  LDD1669  [2]
 LDCM0479  CL85 HEK-293T C23(0.97)  LDD1682  [2]
 LDCM0492  CL97 HEK-293T C23(0.86)  LDD1695  [2]
 LDCM0022  KB02 697 C23(1.23)  LDD2245  [1]
 LDCM0023  KB03 769-P C23(1.20)  LDD2663  [1]
 LDCM0024  KB05 MOLM-13 C23(1.27)  LDD3333  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402