Details of the Target

General Information of Target

Target ID LDTP04070
Target Name Peptidyl-prolyl cis-trans isomerase C (PPIC)
Gene Name PPIC
Gene ID 5480
Synonyms
CYPC; Peptidyl-prolyl cis-trans isomerase C; PPIase C; EC 5.2.1.8; Cyclophilin C; Rotamase C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPGPRLLLPLVLCVGLGALVFSSGAEGFRKRGPSVTAKVFFDVRIGDKDVGRIVIGLFG
KVVPKTVENFVALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVSIYGETFPDE
NFKLKHYGIGWVSMANAGPDTNGSQFFITLTKPTWLDGKHVVFGKVIDGMTVVHSIELQA
TDGHDRPLTNCSIINSGKIDVKTPFVVEIADW
Target Bioclass
Enzyme
Family
Cyclophilin-type PPIase family
Subcellular location
Cytoplasm
Function PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
Uniprot ID
P45877
Ensemble ID
ENST00000306442.5
HGNC ID
HGNC:9256
ChEMBL ID
CHEMBL2424505

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K83(7.11)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K49(1.58)  LDD3494  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888