Details of the Target
General Information of Target
| Target ID | LDTP04067 | |||||
|---|---|---|---|---|---|---|
| Target Name | Aspartoacylase (ASPA) | |||||
| Gene Name | ASPA | |||||
| Gene ID | 443 | |||||
| Synonyms |
ACY2; ASP; Aspartoacylase; EC 3.5.1.15; Aminoacylase-2; ACY-2 |
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| 3D Structure | ||||||
| Sequence |
MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK LTLNAKSIRCCLH |
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| Target Type |
Clinical trial
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| Target Bioclass |
Enzyme
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| Family |
AspA/AstE family, Aspartoacylase subfamily
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| Subcellular location |
Cytoplasm
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| Function |
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it acts as a scavenger of NAA from body fluids.
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| TTD ID | ||||||
| Uniprot ID | ||||||
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Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C276(0.72) | LDD3332 | [1] | |
Competitor(s) Related to This Target