Details of the Target

General Information of Target

Target ID LDTP04066
Target Name Troponin T, cardiac muscle (TNNT2)
Gene Name TNNT2
Gene ID 7139
Synonyms
Troponin T, cardiac muscle; TnTc; Cardiac muscle troponin T; cTnT
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDIEEVVEEYEEEEQEEAAVEEEEDWREDEDEQEEAAEEDAEAEAETEETRAEEDEEEE
EAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHF
ENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAED
EARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLR
EKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
Target Type
Literature-reported
Target Bioclass
Other
Family
Troponin T family
Function Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
TTD ID
T05887
Uniprot ID
P45379
DrugMap ID
TTWAS18
Ensemble ID
ENST00000236918.11
HGNC ID
HGNC:11949
ChEMBL ID
CHEMBL2095202

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.E14A .
CALU6 SNV: p.E153Ter .
LNCaP clone FGC SNV: p.T51N; p.I116V .
NCIH2286 SNV: p.R151L .
SKMEL28 SNV: p.R141L .
SNU5 SNV: p.A42D .
WM115 SNV: p.Q266P .
WM2664 SNV: p.Q266P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K292(10.00)  LDD0277  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270