Details of the Target

General Information of Target

Target ID LDTP04040
Target Name Melanoma-associated antigen 3 (MAGEA3)
Gene Name MAGEA3
Gene ID 4102
Synonyms
MAGE3; Melanoma-associated antigen 3; Antigen MZ2-D; Cancer/testis antigen 1.3; CT1.3; MAGE-3 antigen
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPD
PPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAELVHFL
LLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASSSLQLVFGIELMEVDPIGHLYIFAT
CLGLSYDGLLGDNQIMPKAGLLIIVLAIIAREGDCAPEEKIWEELSVLEVFEGREDSILG
DPKKLLTQHFVQENYLEYRQVPGSDPACYEFLWGPRALVETSYVKVLHHMVKISGGPHIS
YPPLHEWVLREGEE
Target Type
Clinical trial
Target Bioclass
Other
Function
Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
TTD ID
T51693
Uniprot ID
P43357
DrugMap ID
TTWSKHD
Ensemble ID
ENST00000370278.4
HGNC ID
HGNC:6801
ChEMBL ID
CHEMBL4662941

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C10(2.99)  LDD3373  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C10(1.39)  LDD2243  [1]
 LDCM0023  KB03 A2058 C10(0.99)  LDD2670  [1]
 LDCM0024  KB05 OCUG-1 C10(2.99)  LDD3373  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Choline-phosphate cytidylyltransferase A (PCYT1A) Cytidylyltransferase family P49585
AMSH-like protease (STAMBPL1) Peptidase M67C family Q96FJ0
Kinesin-like protein KIF27 (KIF27) Kinesin family Q86VH2
Transcription intermediary factor 1-beta (TRIM28) TRIM/RBCC family Q13263
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Exocyst complex component 5 (EXOC5) SEC10 family O00471
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell CLL/lymphoma 7 protein family member B (BCL7B) BCL7 family Q9BQE9
Cyclin-dependent kinase 2-interacting protein (CINP) CINP family Q9BW66
Protein S100-A9 (S100A9) S-100 family P06702
U6 snRNA-associated Sm-like protein LSm2 (LSM2) SnRNP Sm proteins family Q9Y333
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
Chromatin complexes subunit BAP18 (BAP18) . Q8IXM2

The Drug(s) Related To This Target

Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Astuprotimut-r . D02XYA
Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gl-0817 Small molecular drug D08DUF
Idm-2101 Vaccine D03QMY
Polynoma-1 Vaccine D00DSV
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Kite-718 TCR-T cell therapy DN46RL
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Melanoma Vaccine (Alvac) Vaccine D0C1EO

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255