Details of the Target
General Information of Target
| Target ID | LDTP04026 | |||||
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| Target Name | Cathepsin K (CTSK) |
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| Gene Name | CTSK | |||||
| Gene ID | 1513 | |||||
| Synonyms |
CTSO; CTSO2; Cathepsin K; EC 3.4.22.38; Cathepsin O; Cathepsin O2; Cathepsin X |
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| 3D Structure | ||||||
| Sequence |
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE NWGNKGYILMARNKNNACGIANLASFPKM |
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| Target Type |
Clinical trial
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| Target Bioclass |
Enzyme
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| Family |
Peptidase C1 family
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| Subcellular location |
Lysosome
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| Function |
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
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| TTD ID | ||||||
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Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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HHS-482 Probe Info |
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Y126(0.64) | LDD2239 | [1] | |