Details of the Target

General Information of Target

Target ID LDTP04023
Target Name Carbonic anhydrase 7 (CA7)
Gene Name CA7
Gene ID 766
Synonyms
Carbonic anhydrase 7; EC 4.2.1.1; Carbonate dehydratase VII; Carbonic anhydrase VII; CA-VII
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLS
ITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSEL
HLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSC
FNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDER
IHMVNNFRPPQPLKGRVVKASFRA
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Alpha-carbonic anhydrase family
Subcellular location
Cytoplasm
Function Reversible hydration of carbon dioxide.
TTD ID
T37541
Uniprot ID
P43166
DrugMap ID
TTJC376
Ensemble ID
ENST00000338437.7
HGNC ID
HGNC:1381
ChEMBL ID
CHEMBL2326

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.G65D .
8505C SNV: p.D112H .
HEC1B SNV: p.T174A .
RKO SNV: p.G100D .
SW1573 SNV: p.T110M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		N.A.  LDD2223  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C180(20.00)  LDD2227  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264