Details of the Target
General Information of Target
| Target ID | LDTP04010 | |||||
|---|---|---|---|---|---|---|
| Target Name | Excitatory amino acid transporter 1 (SLC1A3) | |||||
| Gene Name | SLC1A3 | |||||
| Gene ID | 6507 | |||||
| Synonyms |
EAAT1; GLAST; GLAST1; Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 |
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| 3D Structure | ||||||
| Sequence |
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIV
GTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMG MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPP NLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNG VNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGK IVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITAL GTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT TTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSET KM |
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| Target Type |
Literature-reported
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| Target Bioclass |
Transporter and channel
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| Family |
Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family, SLC1A3 subfamily
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| Subcellular location |
Cell membrane
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| Function |
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate . Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate.
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| Uniprot ID | ||||||
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| Ensemble ID | ||||||
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| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| HT115 | SNV: p.A115V | . | |||
| JURKAT | SNV: p.Y44H | . | |||
| MEWO | SNV: p.Q19Ter; p.P392L | . | |||
| OVK18 | SNV: p.V58I | DBIA Probe Info | |||
| PANC1 | SNV: p.K38N | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
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C375(0.91) | LDD3314 | [1] | |
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IPM Probe Info |
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N.A. | LDD2156 | [2] | |
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TFBX Probe Info |
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N.A. | LDD0148 | [3] | |
PAL-AfBPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STS-2 Probe Info |
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N.A. | LDD0138 | [4] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Glutathione S-transferase 3, mitochondrial (MGST3) | MAPEG family | O14880 | |||
Immunoglobulin
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Butyrophilin subfamily 2 member A2 (BTN2A2) | BTN/MOG family | Q8WVV5 | |||
Other
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Transmembrane protein 120B (TMEM120B) | TMEM120 family | A0PK00 | |||
The Drug(s) Related To This Target
Approved
| Drug Name | Drug Type | External ID | |||
|---|---|---|---|---|---|
| Fingolimod | Small molecular drug | DB08868 | |||
| Glutamic Acid | Small molecular drug | DB00142 | |||
Investigative
References