Details of the Target

General Information of Target

Target ID LDTP04006
Target Name Neuronal vesicle trafficking-associated protein 1 (NSG1)
Gene Name NSG1
Gene ID 27065
Synonyms
D4S234; NEEP21; Neuronal vesicle trafficking-associated protein 1; Neuron-enriched endosomal protein of 21 kDa; Neuron-specific protein family member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRKKGK
ARPPQIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVVYKVYKYDRACPDGFVLKN
TQCIPEGLESYYAEQDSSAREKFYTVINHYNLAKQSITRSVSPWMSVLSEEKLSEQETEA
AEKSA
Target Bioclass
Other
Family
NSG family
Subcellular location
Membrane
Function
Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome. In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage.
Uniprot ID
P42857
Ensemble ID
ENST00000397958.5
HGNC ID
HGNC:18790

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH2291 SNV: p.E19Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C112(0.92)  LDD1509  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C112(0.92)  LDD1509  [1]
 LDCM0278  AC19 HEK-293T C112(0.93)  LDD1517  [1]
 LDCM0287  AC27 HEK-293T C112(0.92)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C112(0.98)  LDD1529  [1]
 LDCM0296  AC35 HEK-293T C112(1.00)  LDD1535  [1]
 LDCM0305  AC43 HEK-293T C112(0.91)  LDD1544  [1]
 LDCM0314  AC51 HEK-293T C112(0.83)  LDD1553  [1]
 LDCM0322  AC59 HEK-293T C112(0.98)  LDD1561  [1]
 LDCM0406  CL19 HEK-293T C112(1.00)  LDD1610  [1]
 LDCM0420  CL31 HEK-293T C112(1.09)  LDD1624  [1]
 LDCM0433  CL43 HEK-293T C112(0.96)  LDD1637  [1]
 LDCM0446  CL55 HEK-293T C112(0.99)  LDD1649  [1]
 LDCM0459  CL67 HEK-293T C112(1.03)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C112(1.07)  LDD1665  [1]
 LDCM0472  CL79 HEK-293T C112(0.92)  LDD1675  [1]
 LDCM0486  CL91 HEK-293T C112(0.98)  LDD1689  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402