Details of the Target

General Information of Target

Target ID LDTP04005
Target Name C-X-C motif chemokine 5 (CXCL5)
Gene Name CXCL5
Gene ID 6374
Synonyms
ENA78; SCYB5; C-X-C motif chemokine 5; ENA-78(1-78); Epithelial-derived neutrophil-activating protein 78; Neutrophil-activating peptide ENA-78; Small-inducible cytokine B5) [Cleaved into: ENA-78(8-78; ENA-78(9-78)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLLSSRAARVPGPSSSLCALLVLLLLLTQPGPIASAGPAAAVLRELRCVCLQTTQGVHP
KMISNLQVFAIGPQCSKVEVVASLKNGKEICLDPEAPFLKKVIQKILDGGNKEN
Target Bioclass
Cytokine and receptor
Family
Intercrine alpha (chemokine CxC) family
Subcellular location
Secreted
Function Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.
Uniprot ID
P42830
Ensemble ID
ENST00000296027.5
HGNC ID
HGNC:10642

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C49(0.93); C51(0.93)  LDD0078  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C49(0.93); C51(0.93)  LDD0078  [1]
 LDCM0022  KB02 EFO-21 C91(2.25)  LDD2321  [2]
 LDCM0023  KB03 GB-2 C91(6.63)  LDD2752  [2]
 LDCM0024  KB05 HMCB C91(1.56)  LDD3312  [2]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840