Details of the Target

General Information of Target

Target ID LDTP04002
Target Name Cyclin-dependent kinase 4 inhibitor B (CDKN2B)
Gene Name CDKN2B
Gene ID 1030
Synonyms
MTS2; Cyclin-dependent kinase 4 inhibitor B; Multiple tumor suppressor 2; MTS-2; p14-INK4b; p15-INK4b; p15INK4B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSAR
VAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA
EERGHRDVAGYLRTATGD
Target Bioclass
Other
Family
CDKN2 cyclin-dependent kinase inhibitor family
Subcellular location
Cytoplasm
Function Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
Uniprot ID
P42772
Ensemble ID
ENST00000276925.7
HGNC ID
HGNC:1788

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C Insertion: p.E121delinsDTNAYTer .
A673 SNV: p.E16D .
CHL1 Substitution: p.D76P .
NCIH1993 Substitution: p.D76P .
TOV21G SNV: p.A23V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C74(1.24)  LDD3384  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]
Acrolein
 Probe Info  		N.A.  LDD0217  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0107  IAA HeLa C74(0.00); H100(0.00)  LDD0221  [3]
 LDCM0022  KB02 Caov-3 C74(1.28)  LDD2295  [1]
 LDCM0023  KB03 Caov-3 C74(1.35)  LDD2712  [1]
 LDCM0024  KB05 OVCAR-8 C74(1.24)  LDD3384  [1]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Cyclin-dependent kinase 17 (CDK17) CMGC Ser/Thr protein kinase family Q00537
Cyclin-dependent kinase 4 (CDK4) CMGC Ser/Thr protein kinase family P11802
Cyclin-dependent kinase 6 (CDK6) CMGC Ser/Thr protein kinase family Q00534
Pyrroline-5-carboxylate reductase 3 (PYCR3) Pyrroline-5-carboxylate reductase family Q53H96
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
V-type proton ATPase subunit H (ATP6V1H) V-ATPase H subunit family Q9UI12
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Connector enhancer of kinase suppressor of ras 3 (CNKSR3) CNKSR family Q6P9H4
Cyclin-C (CCNC) Cyclin family P24863
Retrotransposon Gag-like protein 8C (RTL8C) FAM127 family A6ZKI3
Protein INCA1 (INCA1) INCA family Q0VD86
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
Melanoma-associated antigen 11 (MAGEA11) . P43364
PRKCA-binding protein (PICK1) . Q9NRD5
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.