Details of the Target

General Information of Target

Target ID LDTP03964
Target Name T-lymphocyte activation antigen CD86 (CD86)
Gene Name CD86
Gene ID 942
Synonyms
CD28LG2; T-lymphocyte activation antigen CD86; Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD antigen CD86
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQ
ENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGM
IRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTI
EYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQ
PPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREK
IHIPERSDEAQRVFKSSKTSSCDKSDTCF
Target Type
Successful
Target Bioclass
Immunoglobulin
Subcellular location
Cell membrane
Function
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation.; [Isoform 2]: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.; (Microbial infection) Acts as a receptor for adenovirus subgroup B.
TTD ID
T50912
Uniprot ID
P42081
DrugMap ID
TTHGXBU
Ensemble ID
ENST00000264468.9
HGNC ID
HGNC:1705
ChEMBL ID
CHEMBL2364156

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO21 SNV: p.L155F .
HT115 SNV: p.H79Y .
IGR1 SNV: p.Y280S .
IM95 SNV: p.T225M .
MCC13 SNV: p.P242S .
NCIH1793 SNV: p.E291Q .
NCIH1993 SNV: p.E181G .
NUGC3 SNV: p.L130P .
SKMEL5 SNV: p.P247S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C63(1.40)  LDD3370  [1]
IA-alkyne
 Probe Info  		C282(1.84)  LDD2187  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C282(1.84)  LDD2187  [2]
 LDCM0575  Fragment13 Ramos C282(2.36)  LDD2192  [2]
 LDCM0580  Fragment21 Ramos C282(1.10)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C282(1.36)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C282(1.35)  LDD2197  [2]
 LDCM0588  Fragment30 Ramos C282(3.10)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C282(2.42)  LDD2200  [2]
 LDCM0468  Fragment33 Ramos C282(3.52)  LDD2202  [2]
 LDCM0022  KB02 769-P C63(1.87)  LDD2246  [1]
 LDCM0023  KB03 769-P C63(2.19)  LDD2663  [1]
 LDCM0024  KB05 OCI-AML-2 C63(1.40)  LDD3370  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578