Details of the Target
General Information of Target
| Target ID | LDTP03951 | |||||
|---|---|---|---|---|---|---|
| Target Name | Folate receptor gamma (FOLR3) |
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| Gene Name | FOLR3 | |||||
| Gene ID | 2352 | |||||
| Synonyms |
Folate receptor gamma; FR-gamma; Folate receptor 3 |
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| 3D Structure | ||||||
| Sequence |
MDMAWQMMQLLLLALVTAAGSAQPRSARARTDLLNVCMNAKHHKTQPSPEDELYGQCSPW
KKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPTCKRHFIQDSCLYECSPNLGPWIRQV NQSWRKERILNVPLCKEDCERWWEDCRTSYTCKSNWHKGWNWTSGINECPAGALCSTFES YFPTPAALCEGLWSHSFKVSNYSRGSGRCIQMWFDSAQGNPNEEVAKFYAAAMNAGAPSR GIIDS |
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| Target Type |
Literature-reported
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| Target Bioclass |
Other
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| Family |
Folate receptor family
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| Subcellular location |
Secreted
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| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate. | |||||
| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
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Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C152(1.31) | LDD3368 | [1] | |
Competitor(s) Related to This Target