Details of the Target

General Information of Target

Target ID LDTP03941
Target Name Hepatocyte nuclear factor 4-alpha (HNF4A)
Gene Name HNF4A
Gene ID 3172
Synonyms
HNF4; NR2A1; TCF14; Hepatocyte nuclear factor 4-alpha; HNF-4-alpha; Nuclear receptor subfamily 2 group A member 1; Transcription factor 14; TCF-14; Transcription factor HNF-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC
AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC
FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK
IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK
DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK
GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL
FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW
PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
Target Type
Literature-reported
Target Bioclass
Transcription factor
Family
Nuclear hormone receptor family, NR2 subfamily
Subcellular location
Nucleus
Function
Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes. Activates the transcription of CYP2C38. Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells.
TTD ID
T15514
Uniprot ID
P41235
DrugMap ID
TT2F3CD
Ensemble ID
ENST00000316099.10
HGNC ID
HGNC:5024
ChEMBL ID
CHEMBL5398

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C96(0.00); C209(0.00); C255(0.00); C102(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C285(0.78)  LDD3333  [2]
W1
 Probe Info  		C209(0.00); C255(0.00); C96(0.00)  LDD0236  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 769-P C285(2.72)  LDD2246  [2]
 LDCM0023  KB03 769-P C285(5.67)  LDD2663  [2]
 LDCM0024  KB05 MOLM-13 C285(0.78)  LDD3333  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phospholipid phosphatase 2 (PLPP2) PA-phosphatase related phosphoesterase family O43688
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dystrophin (DMD) . P11532
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glucocorticoid receptor (NR3C1) Nuclear hormone receptor family P04150
Prospero homeobox protein 1 (PROX1) Prospero homeodomain family Q92786
Sterol regulatory element-binding protein 2 (SREBF2) SREBP family Q12772
Forkhead box protein O6 (FOXO6) . A8MYZ6
Splicing factor, proline- and glutamine-rich (SFPQ) . P23246
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cbp/p300-interacting transactivator 2 (CITED2) CITED family Q99967
Eukaryotic translation initiation factor 1A, Y-chromosomal (EIF1AY) EIF-1A family O14602
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) . Q9UBK2

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lauric Acid Small molecular drug DB03017
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Avi-4557 Antisense drug DB05447
Bi6015 Small molecular drug D02RRY
Lauric Acid Small molecular drug D0N0UC
Myristic Acid Small molecular drug D08OBF
Myristic Acid Small molecular drug DB08231

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840