Details of the Target

General Information of Target

Target ID LDTP03814
Target Name Arrestin-C (ARR3)
Gene Name ARR3
Gene ID 407
Synonyms
ARRX; CAR; Arrestin-C; Cone arrestin; C-arrestin; cArr; Retinal cone arrestin-3; X-arrestin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKVFKKTSSNGKLSIYLGKRDFVDHVDTVEPIDGVVLVDPEYLKCRKLFVMLTCAFRYG
RDDLEVIGLTFRKDLYVQTLQVVPAESSSPQGPLTVLQERLLHKLGDNAYPFTLQMVTNL
PCSVTLQPGPEDAGKPCGIDFEVKSFCAENPEETVSKRDYVRLVVRKVQFAPPEAGPGPS
AQTIRRFLLSAQPLQLQAWMDREVHYHGEPISVNVSINNCTNKVIKKIKISVDQITDVVL
YSLDKYTKTVFIQEFTETVAANSSFSQSFAVTPILAASCQKRGLALDGKLKHEDTNLASS
TIIRPGMDKELLGILVSYKVRVNLMVSCGGILGDLTASDVGVELPLVLIHPKPSHEAASS
EDIVIEEFTRKGEEESQKAVEAEGDEGS
Target Bioclass
Other
Family
Arrestin family
Subcellular location
Photoreceptor inner segment
Function May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins.
Uniprot ID
P36575
Ensemble ID
ENST00000307959.9
HGNC ID
HGNC:710

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Insertion: p.I228NfsTer6 .
HGC27 SNV: p.R100Ter .
L428 SNV: p.Y160Ter .
MCC13 SNV: p.G12E .
MELJUSO SNV: p.E310K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K289(3.47); K291(4.06)  LDD0277  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270