Details of the Target

General Information of Target

Target ID LDTP03691
Target Name Protein EVI2B (EVI2B)
Gene Name EVI2B
Gene ID 2124
Synonyms
EVDB; Protein EVI2B; Ecotropic viral integration site 2B protein homolog; EVI-2B; CD antigen CD361
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPKYFILILFCGHLNNTFFSKTETITTEKQSQPTLFTSSMSQVLANSQNTTGNPLGQPT
QFSDTFSGQSISPAKVTAGQPTPAVYTSSEKPEAHTSAGQPLAYNTKQPTPIANTSSQQA
VFTSARQLPSARTSTTQPPKSFVYTFTQQSSSVQIPSRKQITVHNPSTQPTSTVKNSPRS
TPGFILDTTSNKQTPQKNNYNSIAAILIGVLLTSMLVAIIIIVLWKCLRKPVLNDQNWAG
RSPFADGETPDICMDNIRENEISTKRTSIISLTPWKPSKSTLLADDLEIKLFESSENIED
SNNPKTEKIKDQVNGTSEDSADGSTVGTAVSSSDDADLPPPPPLLDLEGQESNQSDKPTM
TIVSPLPNDSTSLPPSLDCLNQDCGDHKSEIIQSFPPLDSLNLPLPPVDFMKNQEDSNLE
IQCQEFSIPPNSDQDLNESLPPPPAELL
Target Bioclass
Other
Subcellular location
Membrane
Function Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells.
Uniprot ID
P34910
Ensemble ID
ENST00000330927.5
HGNC ID
HGNC:3500

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Deletion: p.S21QfsTer92 .
LNCaP clone FGC SNV: p.N201D .
MOLT4 SNV: p.T361I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K276(3.42)  LDD0277  [1]
IA-alkyne
 Probe Info  		C253(1.51)  LDD0304  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0131  RA190 MM1.R C253(1.51)  LDD0304  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.