Details of the Target

General Information of Target

Target ID LDTP03686
Target Name Syndecan-2 (SDC2)
Gene Name SDC2
Gene ID 6383
Synonyms
HSPG1; Syndecan-2; SYND2; Fibroglycan; Heparan sulfate proteoglycan core protein; HSPG; CD antigen CD362
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRRAWILLTLGLVACVSAESRAELTSDKDMYLDNSSIEEASGVYPIDDDDYASASGSGAD
EDVESPELTTSRPLPKILLTSAAPKVETTTLNIQNKIPAQTKSPEETDKEKVHLSDSERK
MDPAEEDTNVYTEKHSDSLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYD
LGERKPSSAAYQKAPTKEFYA
Target Type
Literature-reported
Target Bioclass
Other
Family
Syndecan proteoglycan family
Subcellular location
Membrane
Function Cell surface proteoglycan which regulates dendritic arbor morphogenesis.
TTD ID
T80848
Uniprot ID
P34741
DrugMap ID
TT5H2F0
Ensemble ID
ENST00000302190.9
HGNC ID
HGNC:10659
ChEMBL ID
CHEMBL4888448

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K185(4.62); K193(10.00)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K141(1.35); K111(1.38); K134(3.53)  LDD3494  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888