Details of the Target

General Information of Target

Target ID LDTP03675
Target Name Histone H2B type 1-B (H2BC3)
Gene Name H2BC3
Gene ID 3018
Synonyms
H2BFF; HIST1H2BB; Histone H2B type 1-B; H2B-clustered histone 3; Histone H2B.1; Histone H2B.f; H2B/f
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPEPSKSAPAPKKGSKKAITKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK
Target Bioclass
Other
Family
Histone H2B family
Subcellular location
Nucleus
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Uniprot ID
P33778
Ensemble ID
ENST00000615966.2
HGNC ID
HGNC:4751

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K21(5.90)  LDD0277  [1]
HHS-475
 Probe Info  		Y84(1.13)  LDD0264  [2]
HHS-465
 Probe Info  		Y84(2.95)  LDD2237  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y84(1.13)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y84(1.00)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y84(1.27)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y84(1.26)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y84(1.74)  LDD0268  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.