Details of the Target

General Information of Target

Target ID LDTP03657
Target Name Intercellular adhesion molecule 3 (ICAM3)
Gene Name ICAM3
Gene ID 3385
Synonyms
Intercellular adhesion molecule 3; ICAM-3; CDw50; ICAM-R; CD antigen CD50
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSS
EKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERV
ELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLAS
RDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVD
CTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGG
ERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQL
QLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHV
LQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIE
AGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMG
EEPSRAE
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, ICAM family
Subcellular location
Membrane
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages.
Uniprot ID
P32942
Ensemble ID
ENST00000160262.10
HGNC ID
HGNC:5346
ChEMBL ID
CHEMBL3712862

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y519(8.53)  LDD0260  [1]
DBIA
 Probe Info  		C190(13.83); C139(20.44)  LDD0209  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C139(0.00); C190(0.00); C423(0.00); C53(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C139(0.00); C190(0.00); C423(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C190(0.00); C375(0.00); C139(0.00); C407(0.00)  LDD0037  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A3-KAW C407(1.84); C423(1.05)  LDD2257  [5]
 LDCM0023  KB03 Jurkat C190(13.83); C139(20.44)  LDD0209  [2]
 LDCM0024  KB05 MOLM-13 C407(2.49); C423(1.99)  LDD3333  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Claudin-4 (CLDN4) Claudin family O14493
Small integral membrane protein 1 (SMIM1) SMIM1 family B2RUZ4
Translocator protein (TSPO) TspO/BZRP family P30536
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ninjurin-2 (NINJ2) Ninjurin family Q9NZG7
Single-pass membrane and coiled-coil domain-containing protein 4 (SMCO4) SMCO4 family Q9NRQ5
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Epididymal secretory protein E3-beta (EDDM3B) . P56851
Pulmonary surfactant-associated protein C (SFTPC) . P11686

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840