Details of the Target

General Information of Target

Target ID LDTP03650
Target Name 4-hydroxyphenylpyruvate dioxygenase (HPD)
Gene Name HPD
Gene ID 3242
Synonyms
PPD; 4-hydroxyphenylpyruvate dioxygenase; EC 1.13.11.27; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSREVVSH
VIKQGKIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMRE
PWVEQDKFGKVKFAVLQTYGDTTHTLVEKMNYIGQFLPGYEAPAFMDPLLPKLPKCSLEM
IDHIVGNQPDQEMVSASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPI
NEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLR
EKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEVIQRHNHQGFG
AGNFNSLFKAFEEEQNLRGNLTNMETNGVVPGM
Target Type
Successful
Target Bioclass
Enzyme
Family
4HPPD family
Subcellular location
Cytoplasm
Function Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
TTD ID
T07137
Uniprot ID
P32754
DrugMap ID
TT8DSFC
Ensemble ID
ENST00000543163.5
HGNC ID
HGNC:5147
ChEMBL ID
CHEMBL1861

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
IPM
 Probe Info  		N.A.  LDD0025  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nitisinone Small molecular drug D0V1UW
Investigative
Click To Hide/Show 16 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(4-hydroxy-phenoxy)-acetic Acid Small molecular drug D0B7WF
2-(2-bromo-benzoyl)-cyclohexane-1,3-dione Small molecular drug D03FPH
2-(2-chloro-benzoyl)-cyclohexane-1,3-dione Small molecular drug D0C2WX
2-(2-iodo-benzoyl)-cyclohexane-1,3-dione Small molecular drug D02CAT
2-(2-methoxy-benzoyl)-cyclohexane-1,3-dione Small molecular drug D07IWD
2-(2-methyl-benzoyl)-cyclohexane-1,3-dione Small molecular drug D0L8FW
2-(2-nitro-benzoyl)-cyclohexane-1,3-dione Small molecular drug D01TZT
2-acetyl-3-hydroxycyclohex-2-enone Small molecular drug D0R0XE
2-acetyl-cyclohexane-1,3-dione Small molecular drug D0K3BO
2-cyclopropanecarbonyl-cyclohexane-1,3-dione Small molecular drug D0Q7OY
2-propionyl-cyclohexane-1,3-dione Small molecular drug D0MZ9D
3-hydroxy-2-propionylcyclohex-2-enone Small molecular drug D0I6SI
3-hydroxy-4-phenyl-5h-furan-2-one Small molecular drug D0A2EE
Acetate Ion Small molecular drug D0F2ME
Das869 . DB02850
Diketonitrile . D04QZR
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bms-433771 Small molecular drug D08QTP

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255