Details of the Target

General Information of Target

Target ID LDTP03649
Target Name Somatostatin receptor type 3 (SSTR3)
Gene Name SSTR3
Gene ID 6753
Synonyms
Somatostatin receptor type 3; SS-3-R; SS3-R; SS3R; SST3; SSR-28
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLL
GNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVM
AVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVV
FSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRV
WAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVA
LPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEE
SREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL
Target Type
Successful
Target Bioclass
GPCR
Family
G-protein coupled receptor 1 family
Subcellular location
Cell membrane
Function Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
TTD ID
T13644
Uniprot ID
P32745
DrugMap ID
TTJX3UE
Ensemble ID
ENST00000610913.2
HGNC ID
HGNC:11332
ChEMBL ID
CHEMBL2028

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C245(11.51)  LDD1704  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 T cell-activated C245(11.51)  LDD1704  [1]
 LDCM0024  KB05 T cell-activated C245(12.95)  LDD1706  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Somatostatin receptor type 2 (SSTR2) G-protein coupled receptor 1 family P30874
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Multiple PDZ domain protein (MPDZ) . O75970

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pasireotide Small molecular drug D0TV0C
Edotreotide Gallium Ga-68 . DB15494
Lutetium Lu 177 Dotatate . DB13985
Somatostatin . DB09099
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Odt-8 . D06JFI
Investigative
Click To Hide/Show 26 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bn-81,644 Small molecular drug D01BWV
Bn-81,674 Small molecular drug D05JMJ
Cgp 23996 Small molecular drug D0P3WF
Des-aa1,2,4,5,10,12,13-[D-trp8]Srif Small molecular drug D0H0DC
H-d-phe-c[Cys-ala-d-trp-lys-thr-cys]-thr-nh2 Small molecular drug D02CQW
L-796,778 Small molecular drug D05JKQ
Nvp Acq090 Small molecular drug D02MLI
Srif-14 Small molecular drug D0R7OD
Srif-28 Small molecular drug D06WCI
99mtc-mip-1407 . D06WYG
Cytotoxin Peptide Conjugate . D0B5AZ
Des-aa1,2,4,12,13-[D-trp8]Srif . D09DAC
Des-aa1,2,4,13-[D-trp8]Srif . D0C5RH
Des-aa1,2,4,5,13-[D-trp8]-srif . D0Z3LZ
Des-aa1,2,4,5-[D-trp8]Srif . D0J5OY
Des-aa1,2,5,12,13-[D-trp8,Iamp9]Srif . D02NJV
Des-aa1,2,5,12,13-[D-trp8]Srif . D04ORV
Des-aa1,2,5-[D-trp8,(Nalphame)Iamp9]Srif . D0W0AF
Des-aa1,2,5-[D-trp8,Iamp9,M-i-tyr11]Cbm-srif . D0Z0OF
Des-aa1,2,5-[D-trp8,Iamp9]Srif Ch-275 . D02WOX
Des-aa1,2,5-[D-trp8,Tyr11]Srif . D02OJQ
Des-aa1,4,5,13-[Tyr2,D-trp8]-srif . D04FPW
Des-aa1,5-[Tyr2,D-trp8,Iamp9]Cbm-srif . D0N2MA
Des-aa5-[D-trp8]Srif . D0H4WH
H-dphe-c[Cys-phe-dtrp-lys-thr-cys]-thr-nh2 . D05COQ
Somatostatin . D0T5RO
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fr-121196 Small molecular drug D05EKM

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.