Details of the Target

General Information of Target

Target ID LDTP03648
Target Name ETS-related transcription factor Elf-1 (ELF1)
Gene Name ELF1
Gene ID 1997
Synonyms
ETS-related transcription factor Elf-1; E74-like factor 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVVQQNDLVFEFASNVMEDERQLGDPAIFPAVIVEHVPGADILNSYAGLACVEEPNDM
ITESSLDVAEEEIIDDDDDDITLTVEASCHDGDETIETIEAAEALLNMDSPGPMLDEKRI
NNNIFSSPEDDMVVAPVTHVSVTLDGIPEVMETQQVQEKYADSPGASSPEQPKRKKGRKT
KPPRPDSPATTPNISVKKKNKDGKGNTIYLWEFLLALLQDKATCPKYIKWTQREKGIFKL
VDSKAVSRLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLIYIN
DEDPSSSIESSDPSLSSSATSNRNQTSRSRVSSSPGVKGGATTVLKPGNSKAAKPKDPVE
VAQPSEVLRTVQPTQSPYPTQLFRTVHVVQPVQAVPEGEAARTSTMQDETLNSSVQSIRT
IQAPTQVPVVVSPRNQQLHTVTLQTVPLTTVIASTDPSAGTGSQKFILQAIPSSQPMTVL
KENVMLQSQKAGSPPSIVLGPAQVQQVLTSNVQTICNGTVSVASSPSFSATAPVVTFSPR
SSQLVAHPPGTVITSVIKTQETKTLTQEVEKKESEDHLKENTEKTEQQPQPYVMVVSSSN
GFTSQVAMKQNELLEPNSF
Target Bioclass
Transcription factor
Family
ETS family
Subcellular location
Nucleus
Function
Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.
Uniprot ID
P32519
Ensemble ID
ENST00000239882.7
HGNC ID
HGNC:3316

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CMK SNV: p.P457S .
HCT15 SNV: p.A341S .
IPC298 SNV: p.Q444Ter .
NCIH1793 SNV: p.Q505L .
REH SNV: p.P32L; p.V34I .
SW403 SNV: p.A546P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y378(4.32)  LDD0265  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
AOyne
 Probe Info  		15.00  LDD0443  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0117  HHS-0201 DM93 Y378(4.32)  LDD0265  [1]
 LDCM0120  HHS-0701 DM93 Y378(2.25)  LDD0268  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C13 (HOXC13) Abd-B homeobox family P31276
Transcription factor Sp1 (SP1) Sp1 C2H2-type zinc-finger protein family P08047

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.