Details of the Target

General Information of Target

Target ID LDTP03609
Target Name Cytokine receptor common subunit gamma (IL2RG)
Gene Name IL2RG
Gene ID 3561
Synonyms
Cytokine receptor common subunit gamma; Interleukin-2 receptor subunit gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; gammaC; p64; CD antigen CD132
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLKPSLPFTSLLFLQLPLLGVGLNTTILTPNGNEDTTADFFLTTMPTDSLSVSTLPLPEV
QCFVFNVEYMNCTWNSSSEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGCQLQKK
EIHLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWNNRFLN
HCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQHWSEW
SHPIHWGSNTSKENPFLFALEAVVISVGSMGLIISLLCVYFWLERTMPRIPTLKNLEDLV
TEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWAP
PCYTLKPET
Target Bioclass
Cytokine and receptor
Family
Type I cytokine receptor family, Type 5 subfamily
Subcellular location
Cell membrane
Function Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
Uniprot ID
P31785
Ensemble ID
ENST00000374202.7
HGNC ID
HGNC:6010
ChEMBL ID
CHEMBL2364167

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
OVK18 SNV: p.H245Q .
RL952 SNV: p.L160P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C351, C362(18.16)  LDD1707  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 T cell C351, C362(18.16)  LDD1707  [1]
 LDCM0024  KB05 T cell-activated C351(20.00); C362(20.00)  LDD1710  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-7 (IL7) IL-7/IL-9 family P13232
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 5-7 (KRTAP5-7) KRTAP type 5 family Q6L8G8
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aldesleukin BiotechDrug DB00041
Denileukin Diftitox BiotechDrug DB00004
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Resatorvid Small molecular drug DB05943

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.