Details of the Target

General Information of Target

Target ID LDTP03600
Target Name Flavin-containing monooxygenase 3 (FMO3)
Gene Name FMO3
Gene ID 2328
Synonyms
Flavin-containing monooxygenase 3; EC 1.14.13.148; EC 1.14.13.32; EC 1.14.13.8; Dimethylaniline monooxygenase [N-oxide-forming] 3; Dimethylaniline oxidase 3; FMO II; FMO form 2; Hepatic flavin-containing monooxygenase 3; FMO 3; Trimethylamine monooxygenase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEGRASIYKSVFS
NSSKEMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFA
TTGQWDVTTERDGKKESAVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPG
VFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDNGYPWDMLLVTRFG
TFLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVK
PNVKEFTETSAIFEDGTIFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPL
LEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDMMNDINEKMEKKRKWF
GKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWP
GARNAILTQWDRSLKPMQTRVVGRLQKPCFFFHWLKLFAIPILLIAVFLVLT
Target Bioclass
Enzyme
Family
FMO family
Subcellular location
Microsome membrane
Function
Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
Uniprot ID
P31513
Ensemble ID
ENST00000367755.9
HGNC ID
HGNC:3771
ChEMBL ID
CHEMBL3430864

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C397(1.26)  LDD3410  [1]
1d-yne
 Probe Info  		N.A.  LDD0357  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A431 C397(1.56); C466(1.59)  LDD2258  [1]
 LDCM0023  KB03 A431 C397(1.38)  LDD2675  [1]
 LDCM0024  KB05 RPMI-7951 C397(1.26)  LDD3410  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) . Q9NTJ5
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small G protein signaling modulator 3 (SGSM3) Small G protein signaling modulator family Q96HU1
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-type lectin domain family 10 member A (CLEC10A) . Q8IUN9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 15 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Almotriptan Small molecular drug DB00918
Cimetidine Small molecular drug DB00501
Clozapine Small molecular drug DB00363
Dapsone Small molecular drug DB00250
Dasatinib Small molecular drug DB01254
Fedratinib Small molecular drug DB12500
Infigratinib Small molecular drug DB11886
Methimazole Small molecular drug DB00763
Neratinib Small molecular drug DB11828
Olanzapine Small molecular drug DB00334
Olopatadine Small molecular drug DB00768
Propiverine Small molecular drug DB12278
Tamoxifen Small molecular drug DB00675
Vandetanib Small molecular drug DB05294
Voriconazole Small molecular drug DB00582

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.