Details of the Target

General Information of Target

Target ID LDTP03597
Target Name Syndecan-4 (SDC4)
Gene Name SDC4
Gene ID 6385
Synonyms
Syndecan-4; SYND4; Amphiglycan; Ryudocan core protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFEL
SGSGDLDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVE
ESEDVSNKVSMSSTVQGSNIFERTEVLAALIVGGIVGILFAVFLILLLMYRMKKKDEGSY
DLGKKPIYKKAPTNEFYA
Target Bioclass
Transporter and channel
Family
Syndecan proteoglycan family
Subcellular location
Secreted; Membrane
Function Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
Uniprot ID
P31431
Ensemble ID
ENST00000372733.3
HGNC ID
HGNC:10661

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MDAMB468 SNV: p.A2S .
SUDHL6 SNV: p.G96V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
OPA-S-S-alkyne
 Probe Info  		K105(3.81); K114(3.81); K104(3.81)  LDD3494  [2]
Probe 1
 Probe Info  		Y180(11.47)  LDD3495  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myelin and lymphocyte protein (MAL) MAL family P21145
Peripheral myelin protein 22 (PMP22) PMP-22/EMP/MP20 family Q01453
Syndecan-4 (SDC4) Syndecan proteoglycan family P31431
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 179 (GPR179) G-protein coupled receptor 3 family Q6PRD1
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-7 receptor subunit alpha (IL7R) Type I cytokine receptor family P16871
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
Syndecan-2 (SDC2) Syndecan proteoglycan family P34741
Syndecan-3 (SDC3) Syndecan proteoglycan family O75056

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.