Details of the Target
General Information of Target
| Target ID | LDTP03562 | |||||
|---|---|---|---|---|---|---|
| Target Name | Somatostatin receptor type 1 (SSTR1) | |||||
| Gene Name | SSTR1 | |||||
| Gene ID | 6751 | |||||
| Synonyms |
Somatostatin receptor type 1; SS-1-R; SS1-R; SS1R; SST1; SRIF-2 |
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| 3D Structure | ||||||
| Sequence |
MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAIL
ISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLL RHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLG VWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAIC LCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQD DATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKS RAYSVEDFQPENLESGGVFRNGTCTSRITTL |
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| Target Type |
Successful
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| Target Bioclass |
GPCR
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| Family |
G-protein coupled receptor 1 family
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| Subcellular location |
Cell membrane
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| Function |
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
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| TTD ID | ||||||
| Uniprot ID | ||||||
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| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IA-alkyne Probe Info |
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N.A. | LDD2241 | [1] | |