Details of the Target

General Information of Target

Target ID LDTP03561
Target Name Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)
Gene Name ALDH3A1
Gene ID 218
Synonyms
ALDH3; Aldehyde dehydrogenase, dimeric NADP-preferring; EC 1.2.1.5; ALDHIII; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
Target Bioclass
Enzyme
Family
Aldehyde dehydrogenase family
Subcellular location
Cytoplasm
Function
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins. May play a role in preventing corneal damage caused by ultraviolet light.
Uniprot ID
P30838
Ensemble ID
ENST00000225740.11
HGNC ID
HGNC:405
ChEMBL ID
CHEMBL3578

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		E210(0.90)  LDD2208  [1]
DBIA
 Probe Info  		C344(1.06)  LDD3321  [2]
BTD
 Probe Info  		C217(1.80)  LDD1700  [3]
IA-alkyne
 Probe Info  		C244(0.00); C428(0.00); C217(0.00); C344(0.00)  LDD0162  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
WYneN
 Probe Info  		C217(0.00); C428(0.00); C223(0.00); C244(0.00)  LDD0021  [6]
WYneO
 Probe Info  		C428(0.00); C244(0.00); C217(0.00); C229(0.00)  LDD0022  [6]
Acrolein
 Probe Info  		H203(0.00); C244(0.00); C229(0.00)  LDD0217  [7]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [7]
HHS-475
 Probe Info  		Y305(1.32)  LDD2238  [8]
HHS-482
 Probe Info  		Y186(0.85); Y315(1.13)  LDD2239  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C217(0.60)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C217(1.02)  LDD2152  [3]
 LDCM0108  Chloroacetamide HeLa H53(0.00); H203(0.00); C229(0.00)  LDD0222  [7]
 LDCM0107  IAA HeLa H203(0.00); H53(0.00); C229(0.00)  LDD0221  [7]
 LDCM0022  KB02 A-172 C344(0.94)  LDD2251  [2]
 LDCM0023  KB03 A-172 C344(1.31)  LDD2668  [2]
 LDCM0024  KB05 SH4 C344(1.06)  LDD3321  [2]
 LDCM0109  NEM HeLa H203(0.00); H53(0.00)  LDD0223  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C217(1.07)  LDD2093  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C217(0.98)  LDD2107  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C217(0.87)  LDD2123  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C217(1.08)  LDD2136  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C217(1.80)  LDD1700  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C217(3.53)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C217(1.20)  LDD2146  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6) FKBP6 family O75344
Protection of telomeres protein 1 (POT1) Telombin family Q9NUX5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.