Details of the Target

General Information of Target

Target ID LDTP03556
Target Name Glutathione S-transferase theta-1 (GSTT1)
Gene Name GSTT1
Gene ID 2952
Synonyms
Glutathione S-transferase theta-1; EC 2.5.1.18; GST class-theta-1; Glutathione transferase T1-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGQHLSDAFAQVNPLKKVPALKDG
DFTLTESVAILLYLTRKYKVPDYWYPQDLQARARVDEYLAWQHTTLRRSCLRALWHKVMF
PVFLGEPVSPQTLAATLAELDVTLQLLEDKFLQNKAFLTGPHISLADLVAITELMHPVGA
GCQVFEGRPKLATWRQRVEAAVGEDLFQEAHEVILKAKDFPPADPTIKQKLMPWVLAMIR
Target Bioclass
Enzyme
Family
GST superfamily, Theta family
Subcellular location
Cytoplasm
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
Uniprot ID
P30711
Ensemble ID
ENST00000612885.3
HGNC ID
HGNC:4641
ChEMBL ID
CHEMBL2141

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C14(1.38)  LDD3314  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 COR-L88 C14(1.23)  LDD2311  [1]
 LDCM0023  KB03 COR-L88 C14(1.52)  LDD2728  [1]
 LDCM0024  KB05 IGR37 C14(1.38)  LDD3314  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264