Details of the Target
General Information of Target
| Target ID | LDTP03501 | |||||
|---|---|---|---|---|---|---|
| Target Name | Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (PDHA2) | |||||
| Gene Name | PDHA2 | |||||
| Gene ID | 5161 | |||||
| Synonyms |
PDHAL; Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial; EC 1.2.4.1; PDHE1-A type II |
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| 3D Structure | ||||||
| Sequence |
MLAAFISRVLRRVAQKSARRVLVASRNSSNDATFEIKKCDLYLLEEGPPVTTVLTRAEGL
KYYRMMLTVRRMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPSDHVITSYRAHG VCYTRGLSVRSILAELTGRRGGCAKGKGGSMHMYTKNFYGGNGIVGAQGPLGAGIALACK YKGNDEICLTLYGDGAANQGQIAEAFNMAALWKLPCVFICENNLYGMGTSTERAAASPDY YKRGNFIPGLKVDGMDVLCVREATKFAANYCRSGKGPILMELQTYRYHGHSMSDPGVSYR TREEIQEVRSKRDPIIILQDRMVNSKLATVEELKEIGAEVRKEIDDAAQFATTDPEPHLE ELGHHIYSSDSSFEVRGANPWIKFKSVS |
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| Target Bioclass |
Enzyme
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| Subcellular location |
Mitochondrion matrix
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| Function | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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HHS-465 Probe Info |
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N.A. | LDD2240 | [1] | |