Details of the Target

General Information of Target

Target ID LDTP03460
Target Name T-cell surface glycoprotein CD1b (CD1B)
Gene Name CD1B
Gene ID 910
Synonyms
T-cell surface glycoprotein CD1b; CD antigen CD1b
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLLPFQLLAVLFPGGNSEHAFQGPTSFHVIQTSSFTNSTWAQTQGSGWLDDLQIHGWDS
DSGTAIFLKPWSKGNFSDKEVAELEEIFRVYIFGFAREVQDFAGDFQMKYPFEIQGIAGC
ELHSGGAIVSFLRGALGGLDFLSVKNASCVPSPEGGSRAQKFCALIIQYQGIMETVRILL
YETCPRYLLGVLNAGKADLQRQVKPEAWLSSGPSPGPGRLQLVCHVSGFYPKPVWVMWMR
GEQEQQGTQLGDILPNANWTWYLRATLDVADGEAAGLSCRVKHSSLEGQDIILYWRNPTS
IGSIVLAIIVPSLLLLLCLALWYMRRRSYQNIP
Target Bioclass
Immunoglobulin
Subcellular location
Cell membrane
Function Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Uniprot ID
P29016
Ensemble ID
ENST00000368168.4
HGNC ID
HGNC:1635

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.M239I .
DU145 SNV: p.Q289H .
HCC44 SNV: p.G104V .
KMS27 SNV: p.E86D .
MDAMB468 SNV: p.A135T .
MDST8 SNV: p.Q107Ter .
MM1S SNV: p.W235S .
NCIH196 SNV: p.V129A .
NCIH661 SNV: p.L2M .
SBC5 SNV: p.V129E .
SW1271 SNV: p.V269M .
SW403 SNV: p.Q221Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C184(0.00); C120(0.00); C224(0.00)  LDD0167  [1]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-2-microglobulin (B2M) Beta-2-microglobulin family P61769

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853