Details of the Target

General Information of Target

Target ID LDTP03434
Target Name Alcohol dehydrogenase 6 (ADH6)
Gene Name ADH6
Gene ID 130
Synonyms
Alcohol dehydrogenase 6; EC 1.1.1.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTTGQVIRCKAAILWKPGAPFSIEEVEVAPPKAKEVRIKVVATGLCGTEMKVLGSKHLD
LLYPTILGHEGAGIVESIGEGVSTVKPGDKVITLFLPQCGECTSCLNSEGNFCIQFKQSK
TQLMSDGTSRFTCKGKSIYHFGNTSTFCEYTVIKEISVAKIDAVAPLEKVCLISCGFSTG
FGAAINTAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIGVDVNKEKFKKAQELGATE
CLNPQDLKKPIQEVLFDMTDAGIDFCFEAIGNLDVLAAALASCNESYGVCVVVGVLPASV
QLKISGQLFFSGRSLKGSVFGGWKSRQHIPKLVADYMAEKLNLDPLITHTLNLDKINEAV
ELMKTGKW
Target Bioclass
Enzyme
Family
Zinc-containing alcohol dehydrogenase family, Class-V subfamily
Subcellular location
Cytoplasm
Function Alcohol dehydrogenase. Catalyzes the NAD-dependent oxidation of primary alcohols to the corresponding aldehydes. Oxidizes secondary alcohols to the corresponding ketones.
Uniprot ID
P28332
Ensemble ID
ENST00000237653.11
HGNC ID
HGNC:255
ChEMBL ID
CHEMBL2096668

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C241(1.75); C47(1.41)  LDD3346  [2]
W1
 Probe Info  		N.A.  LDD0236  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Hep 3B2.1-7 C241(1.42); C47(1.50)  LDD2353  [2]
 LDCM0023  KB03 Hep 3B2.1-7 C241(2.38); C47(2.37)  LDD2770  [2]
 LDCM0024  KB05 NCI-H1666 C241(1.75); C47(1.41)  LDD3346  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Abacavir Small molecular drug DB01048
Ethanol Small molecular drug DB00898
Nadh Small molecular drug DB00157

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840