Details of the Target

General Information of Target

Target ID LDTP03427
Target Name Protein-lysine 6-oxidase (LOX)
Gene Name LOX
Gene ID 4015
Synonyms
Protein-lysine 6-oxidase; EC 1.4.3.13; Lysyl oxidase) [Cleaved into: Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSL
GSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPT
ARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDD
NPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAA
EENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDE
FSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADID
CQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Lysyl oxidase family
Subcellular location
Secreted
Function
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture.
TTD ID
T75152
Uniprot ID
P28300
DrugMap ID
TT4E26T
Ensemble ID
ENST00000231004.5
HGNC ID
HGNC:6664
ChEMBL ID
CHEMBL2249

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.58  LDD0402  [1]
DBIA
 Probe Info  		C238(1.02); C244(1.02)  LDD0078  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C238(1.02); C244(1.02)  LDD0078  [2]
 LDCM0022  KB02 HCT 116 C238(14.12); C244(14.12)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C238(4.59); C244(4.59)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C238(5.76); C244(5.76)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Plasminogen (PLG) Peptidase S1 family P00747
Receptor-type tyrosine-protein phosphatase kappa (PTPRK) Protein-tyrosine phosphatase family Q15262
Protein-glutamine gamma-glutamyltransferase 2 (TGM2) Transglutaminase family P21980
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dermatopontin (DPT) Dermatopontin family Q07507
Elastin (ELN) Elastin family P15502
Fibrillin-1 (FBN1) Fibrillin family P35555
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Fibulin-5 (FBLN5) Fibulin family Q9UBX5
Fibronectin (FN1) . P02751

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.