Details of the Target

General Information of Target

Target ID LDTP03412
Target Name Proteasome subunit beta type-9 (PSMB9)
Gene Name PSMB9
Gene ID 5698
Synonyms
LMP2; PSMB6i; RING12; Proteasome subunit beta type-9; EC 3.4.25.1; Low molecular mass protein 2; Macropain chain 7; Multicatalytic endopeptidase complex chain 7; Proteasome chain 7; Proteasome subunit beta-1i; Really interesting new gene 12 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHER
IYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMV
AGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIA
LAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Peptidase T1B family
Subcellular location
Cytoplasm
Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
TTD ID
T06792
Uniprot ID
P28065
DrugMap ID
TTOUSTQ
Ensemble ID
ENST00000374859.3
HGNC ID
HGNC:9546
ChEMBL ID
CHEMBL1944495

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.P93H .
TOV21G SNV: p.R3Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K109(0.09)  LDD0277  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		C63(0.00); C171(0.00)  LDD0037  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit beta type-7 (PSMB7) Peptidase T1B family Q99436
Nuclear receptor coactivator 1 (NCOA1) SRC/p160 nuclear receptor coactivator family Q15788
Nuclear receptor coactivator 3 (NCOA3) SRC/p160 nuclear receptor coactivator family Q9Y6Q9
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutamate receptor-interacting protein 1 (GRIP1) . Q9Y3R0
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
EKC/KEOPS complex subunit LAGE3 (LAGE3) CTAG/PCC1 family Q14657
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Proteasome maturation protein (POMP) POMP/UMP1 family Q9Y244

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Carfilzomib Small molecular drug DB08889
Patented
Click To Hide/Show 11 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dipeptide Analog 1 Small molecular drug D0B0GG
Peptide Analog 14 Small molecular drug D0R8XD
Peptide Analog 21 Small molecular drug D02PJI
Peptide Analog 23 Small molecular drug D0T1YB
Peptide Analog 41 Small molecular drug D01OOO
Pmid29865878-compound-46 Small molecular drug D0C2MH
Pmid29865878-compound-48 Small molecular drug D0K0GJ
Pmid29865878-compound-49 Small molecular drug D0TU5R
Pmid29865878-compound-51 Small molecular drug D0NE8M
Pmid29865878-compound-53 Small molecular drug D01VMN
Pmid29865878-compound-55 Small molecular drug D03CMD

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853