General Information of Target

Target ID LDTP03335
Target Name Rhombotin-1 (LMO1)
Gene Name LMO1
Gene ID 4004
Synonyms
RBTN1; RHOM1; TTG1; Rhombotin-1; Cysteine-rich protein TTG-1; LIM domain only protein 1; LMO-1; T-cell translocation protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMVLDKEDGVPMLSVQPKGKQKGCAGCNRKIKDRYLLKALDKYWHEDCLKCACCDCRLGE
VGSTLYTKANLILCRRDYLRLFGTTGNCAACSKLIPAFEMVMRARDNVYHLDCFACQLCN
QRFCVGDKFFLKNNMILCQMDYEEGQLNGTFESQVQ
Target Bioclass
Other
Subcellular location
Nucleus
Function May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.
Uniprot ID
P25800
Ensemble ID
ENST00000335790.8
HGNC ID
HGNC:6641

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1143 SNV: p.E7G .
HT115 SNV: p.E99K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C334(1.77)  LDD3423  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A673 C334(1.53)  LDD2261  [1]
 LDCM0023  KB03 A673 C334(1.93)  LDD2678  [1]
 LDCM0024  KB05 SK-ES1 C334(1.77)  LDD3423  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840