Details of the Target

General Information of Target

Target ID LDTP03334
Target Name Rhombotin-2 (LMO2)
Gene Name LMO2
Gene ID 4005
Synonyms
RBTN2; RBTNL1; RHOM2; TTG2; Rhombotin-2; Cysteine-rich protein TTG-2; LIM domain only protein 2; LMO-2; T-cell translocation protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSAIERKSLDPSEEPVDEVLQIPPSLLTCGGCQQNIGDRYFLKAIDQYWHEDCLSCDLC
GCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCASCDKRIRAYEMTMRVKDKVYHLECF
KCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKINGMI
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Nucleus
Function Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
TTD ID
T88321
Uniprot ID
P25791
DrugMap ID
TTFX379
Ensemble ID
ENST00000257818.3
HGNC ID
HGNC:6642
ChEMBL ID
CHEMBL3217402

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C122(3.94)  LDD2229  [1]
DBIA
 Probe Info  		C199(2.69)  LDD3334  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 697 C199(1.23)  LDD2245  [2]
 LDCM0023  KB03 697 C199(1.10)  LDD2662  [2]
 LDCM0024  KB05 MOLM-16 C199(2.69)  LDD3334  [2]

References

1 A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes. Nat Protoc. 2020 Sep;15(9):2891-2919. doi: 10.1038/s41596-020-0352-2. Epub 2020 Jul 20.
Mass spectrometry data entry: PXD016048
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840