General Information of Target

Target ID LDTP03318
Target Name Zinc-alpha-2-glycoprotein (AZGP1)
Gene Name AZGP1
Gene ID 563
Synonyms
ZAG; ZNGP1; Zinc-alpha-2-glycoprotein; Zn-alpha-2-GP; Zn-alpha-2-glycoprotein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVRMVPVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFR
YNSKDRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSNGSHVLQGR
FGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRAKA
YLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVHWT
RAGEVQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPWEAS
Target Type
Literature-reported
Target Bioclass
Immunoglobulin
Family
MHC class I family
Subcellular location
Secreted
Function Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.
TTD ID
T05249
Uniprot ID
P25311
DrugMap ID
TTUPYLV
Ensemble ID
ENST00000292401.9
HGNC ID
HGNC:910

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C186(1.41)  LDD3318  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AU565 C225(2.02)  LDD2265  [1]
 LDCM0023  KB03 AU565 C225(2.60)  LDD2682  [1]
 LDCM0024  KB05 MELHO C186(1.41)  LDD3318  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840