Details of the Target
General Information of Target
| Target ID | LDTP03270 | |||||
|---|---|---|---|---|---|---|
| Target Name | Alanine aminotransferase 1 (GPT) | |||||
| Gene Name | GPT | |||||
| Gene ID | 2875 | |||||
| Synonyms |
AAT1; GPT1; Alanine aminotransferase 1; ALT1; EC 2.6.1.2; Glutamate pyruvate transaminase 1; GPT 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1 |
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| 3D Structure | ||||||
| Sequence |
MASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQELRQGVKKPF
TEVIRANIGDAQAMGQRPITFLRQVLALCVNPDLLSSPNFPDDAKKRAERILQACGGHSL GAYSVSSGIQLIREDVARYIERRDGGIPADPNNVFLSTGASDAIVTVLKLLVAGEGHTRT GVLIPIPQYPLYSATLAELGAVQVDYYLDEERAWALDVAELHRALGQARDHCRPRALCVI NPGNPTGQVQTRECIEAVIRFAFEERLFLLADEVYQDNVYAAGSQFHSFKKVLMEMGPPY AGQQELASFHSTSKGYMGECGFRGGYVEVVNMDAAVQQQMLKLMSVRLCPPVPGQALLDL VVSPPAPTDPSFAQFQAEKQAVLAELAAKAKLTEQVFNEAPGISCNPVQGAMYSFPRVQL PPRAVERAQELGLAPDMFFCLRLLEETGICVVPGSGFGQREGTYHFRMTILPPLEKLRLL LEKLSRFHAKFTLEYS |
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| Target Bioclass |
Enzyme
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| Family |
Class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfamily
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| Subcellular location |
Cytoplasm
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| Function |
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C254(0.87) | LDD3346 | [2] | |
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Lodoacetamide azide Probe Info |
 |
N.A. | LDD0037 | [3] | |
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TFBX Probe Info |
 |
N.A. | LDD0027 | [4] | |
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Phosphinate-6 Probe Info |
 |
N.A. | LDD0018 | [5] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References