Details of the Target
General Information of Target
| Target ID | LDTP03263 | |||||
|---|---|---|---|---|---|---|
| Target Name | Sodium-dependent noradrenaline transporter (SLC6A2) | |||||
| Gene Name | SLC6A2 | |||||
| Gene ID | 6530 | |||||
| Synonyms |
NAT1; NET1; SLC6A5; Sodium-dependent noradrenaline transporter; Norepinephrine transporter; NET; Solute carrier family 6 member 2 |
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| 3D Structure | ||||||
| Sequence |
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL VAQRDIRQFQLQHWLAI |
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| Target Type |
Successful
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| Target Bioclass |
Transporter and channel
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| Family |
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A2 subfamily
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| Subcellular location |
Cell membrane
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| Function | Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Can also mediate sodium- and chloride-dependent transport of dopamine. | |||||
| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| EGI1 | SNV: p.D187N | DBIA Probe Info | |||
| HCC15 | SNV: p.V492F | DBIA Probe Info | |||
| HCT15 | SNV: p.V148A | . | |||
| HEC1 | SNV: p.A360T | . | |||
| HEC1B | SNV: p.A360T | . | |||
| MEWO | Substitution: p.L237G | . | |||
| NCIH2122 | SNV: p.G255W | . | |||
| SNU1 | SNV: p.G290A | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C39(2.06) | LDD3323 | [1] | |
Competitor(s) Related to This Target