Details of the Target

General Information of Target

Target ID LDTP03255
Target Name Endothelial transcription factor GATA-2 (GATA2)
Gene Name GATA2
Gene ID 2624
Synonyms
Endothelial transcription factor GATA-2; GATA-binding protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYY
ANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSP
FSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKE
VSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLATMGTQP
ATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGA
TATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLW
RRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECFEELSKC
MQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.
Uniprot ID
P23769
Ensemble ID
ENST00000341105.7
HGNC ID
HGNC:4171
ChEMBL ID
CHEMBL4523206

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CMK SNV: p.G167S .
HCT116 Deletion: p.G200VfsTer18 .
HEC1 SNV: p.C370Y .
LS180 SNV: p.M388T .
MELJUSO SNV: p.G273R .
MFE319 Deletion: p.G150EfsTer68 .
NCIH1155 SNV: p.K123N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C413(0.95)  LDD3340  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HEK-293T C316(1.00); C319(1.00)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C316(1.08); C319(1.08)  LDD1497  [3]
 LDCM0024  KB05 NB1 C413(0.95)  LDD3340  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit alpha type-3 (PSMA3) Peptidase T1A family P25788
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
CREB-binding protein (CREBBP) . Q92793
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 4 (SMAD4) Dwarfin/SMAD family Q13485
Transcription factor PU.1 (SPI1) ETS family P17947
Homeobox protein MSX-2 (MSX2) Msh homeobox family P35548
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Progranulin (GRN) Granulin family P28799
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Keratin-associated protein 7-1 (KRTAP7-1) KRTAP type 7 family Q8IUC3
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Keratin-associated protein 13-3 (KRTAP13-3) PMG family Q3SY46
Proline-rich protein 20C (PRR20C) PRR20 family P86479
Four and a half LIM domains protein 3 (FHL3) . Q13643
Keratin-associated protein 21-2 (KRTAP21-2) . Q3LI59
RING finger protein 11 (RNF11) . Q9Y3C5
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402