Details of the Target

General Information of Target

Target ID LDTP03232
Target Name Receptor-type tyrosine-protein phosphatase delta (PTPRD)
Gene Name PTPRD
Gene ID 5789
Synonyms
Receptor-type tyrosine-protein phosphatase delta; Protein-tyrosine phosphatase delta; R-PTP-delta; EC 3.1.3.48
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH
EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV
EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDT
TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL
IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK
VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD
INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF
AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS
YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY
YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP
TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI
TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE
LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN
KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW
RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL
YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT
GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP
YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV
RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV
LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Receptor class 2A subfamily
Subcellular location
Membrane
Function
Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.
Uniprot ID
P23468
Ensemble ID
ENST00000355233.9
HGNC ID
HGNC:9668

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.G272R .
AGS SNV: p.D1871H .
COLO792 SNV: p.E661K .
CORL23 SNV: p.V730D; p.D778H .
CORL88 SNV: p.G446V .
EOL1 SNV: p.P1690T .
GAMG SNV: p.V1284D .
HCT15 SNV: p.S623F; p.P852L; p.N1617S .
HEC1 SNV: p.N1074D; p.R1762W .
HEC1B SNV: p.R1762W .
ICC3 SNV: p.F1873L .
JURKAT SNV: p.T933I .
KMS11 SNV: p.L1036V .
LNCaP clone FGC SNV: p.R83S; p.G574R .
LU65 SNV: p.G1750C .
MCF7 SNV: p.Q1597Ter .
MEC1 SNV: p.Q774L .
MEWO SNV: p.R189K .
MFE319 SNV: p.T1497A; p.G1868Ter .
NCIH1155 SNV: p.T686I .
NCIH1944 SNV: p.Q774L .
NCIH2286 SNV: p.C45Ter .
NCIH716 SNV: p.K1070N .
OVCAR5 SNV: p.R1181L .
OVK18 SNV: p.L534F .
RKO SNV: p.P265T .
TE4 SNV: p.D808E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C1668(1.03)  LDD2093  [1]
IPM
 Probe Info  		C1668(10.78); C1687(6.50)  LDD1701  [1]
DBIA
 Probe Info  		C1465(1.17)  LDD0080  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1687(0.96)  LDD2117  [1]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1668(2.81)  LDD1702  [1]
 LDCM0022  KB02 HCT 116 C1465(1.17)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C1465(1.28)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C1465(1.08)  LDD0082  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1668(1.03)  LDD2093  [1]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1668(1.29)  LDD2105  [1]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1668(0.72)  LDD2111  [1]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1687(0.71)  LDD2125  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1668(0.82)  LDD2127  [1]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1668(0.82)  LDD2129  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1687(0.86)  LDD2136  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1687(1.25)  LDD2137  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1687(0.84)  LDD2140  [1]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1687(0.72)  LDD2144  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aurora kinase A (AURKA) Ser/Thr protein kinase family O14965

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264