Details of the Target

General Information of Target

Target ID LDTP03206
Target Name AMP deaminase 1 (AMPD1)
Gene Name AMPD1
Gene ID 270
Synonyms
AMP deaminase 1; EC 3.5.4.6; AMP deaminase isoform M; Myoadenylate deaminase
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPLFKLPAEEKQIDDAMRNFAEKVFASEVKDEGGRQEISPFDVDEICPISHHEMQAHIFH
LETLSTSTEARRKKRFQGRKTVNLSIPLSETSSTKLSHIDEYISSSPTYQTVPDFQRVQI
TGDYASGVTVEDFEIVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEAWVANESF
YPVFTPPVKKGEDPFRTDNLPENLGYHLKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTF
LDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKV
DTHIHAAACMNQKHLLRFIKKSYQIDADRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSL
DVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVEAKYQ
HAEPRLSIYGRSPDEWSKLSSWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLE
NIFMPVFEATINPQADPELSVFLKHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPS
YTYYAYYMYANIMVLNSLRKERGMNTFLFRPHCGEAGALTHLMTAFMIADDISHGLNLKK
SPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEP
LMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNV
AQIRMAYRYETWCYELNLIAEGLKSTE
Target Bioclass
Enzyme
Family
Metallo-dependent hydrolases superfamily, Adenosine and AMP deaminases family
Function AMP deaminase plays a critical role in energy metabolism.
Uniprot ID
P23109
Ensemble ID
ENST00000369538.4
HGNC ID
HGNC:468
ChEMBL ID
CHEMBL2869

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.D238N .
EFO21 SNV: p.K517I .
FADU SNV: p.S333R .
HCT15 SNV: p.T405A .
HS936T SNV: p.P159L .
HT115 SNV: p.T340A .
IM95 SNV: p.W455R .
KARPAS422 SNV: p.K23E .
MELJUSO SNV: p.H52Y .
MOLT4 Deletion: p.T161PfsTer15 .
RVH421 SNV: p.E343K .
SKMEL30 SNV: p.W455Ter .
TC71 Deletion: p.K149NfsTer27 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C766(1.08)  LDD3411  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 KMS-27 C478(1.03); C766(1.21)  LDD2424  [1]
 LDCM0023  KB03 KMS11 C478(2.33)  LDD2839  [1]
 LDCM0024  KB05 RPMI-8226 C766(1.08)  LDD3411  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840