Details of the Target
General Information of Target
| Target ID | LDTP03202 | |||||
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| Target Name | Macrophage mannose receptor 1 (MRC1) |
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| Gene Name | MRC1 | |||||
| Gene ID | 4360 | |||||
| Synonyms |
CLEC13D; CLEC13DL; MRC1L1; Macrophage mannose receptor 1; MMR; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Human mannose receptor; hMR; Macrophage mannose receptor 1-like protein 1; CD antigen CD206
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| 3D Structure | ||||||
| Sequence |
MRLPLLLVFASVIPGAVLLLDTRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRW
VSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYG NRQEKNIMLYKGSGLWSRWKIYGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYA DCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTW HQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRY LNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTLNSFVIPSESDVPT HCPSQWWPYAGHCYKIHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPND ELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEW PLGYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTFAEANQTCNNENAYLT TIEDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGC VAMRTGIAGGLWDVLKCDEKAKFVCKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCF KLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYG SPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQ KGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQS ESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCV TMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIF GFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTF LWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQ TRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNA FAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWK TAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQAS LECLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNW NTGDPSGERNDCVALHASSGFWSNIHCSSYKGYICKRPKIIDAKPTHELLTTKADTRKMD PSKPSSNVAGVVIIVILLILTGAGLAAYFFYKKRRVHLPQEGAFENTLYFNSQSSPGTSD MKDLVGNIEQNEHSVI |
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| Target Type |
Literature-reported
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| Target Bioclass |
Other
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| Subcellular location |
Endosome membrane
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| Function |
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.; (Microbial infection) Acts as a phagocytic receptor for bacteria, fungi and other pathogens.; (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.; (Microbial infection) Interacts with Hepatitis B virus envelope protein.
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| TTD ID | ||||||
| Uniprot ID | ||||||
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| Ensemble ID | ||||||
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| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| A498 | SNV: p.C977F | . | |||
| CAL78 | SNV: p.P638H | . | |||
| COLO792 | SNV: p.S1086F | DBIA Probe Info | |||
| DU145 | SNV: p.S315R | . | |||
| HCC15 | Deletion: p.G343AfsTer5 | . | |||
| HCT116 | SNV: p.Y369H | . | |||
| JURKAT | SNV: p.R187W | . | |||
| KARPAS422 | SNV: p.C316R | . | |||
| LUDLU1 | SNV: p.G1076V | . | |||
| MCAS | SNV: p.E96V | . | |||
| MCC13 | SNV: p.G1422S | . | |||
| MEWO | SNV: p.S1108L | . | |||
| MOLT4 | SNV: p.W1116Ter | . | |||
| NCIH1793 | SNV: p.A1142G | . | |||
| NCIH2170 | Deletion: p.E461del | . | |||
| NCIH2172 | Substitution: p.P638Q | . | |||
| NCIH2291 | SNV: p.G186W | . | |||
| NCIH23 | SNV: p.P1136T | . | |||
| NCIH3122 | SNV: p.C1052S | . | |||
| NCIH661 | SNV: p.T1148I | . | |||
| SISO | SNV: p.E54K | . | |||
| SNU1 | SNV: p.V799A | . | |||
| SUPT1 | Deletion: p.L26Ter | . | |||
| SW1271 | SNV: p.Y1209F | . | |||
| SW403 | SNV: p.W650C | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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DBIA Probe Info |
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C74(2.41) | LDD3409 | [1] | |
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IPM Probe Info |
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C659(2.60) | LDD1701 | [2] | |
Competitor(s) Related to This Target
References