Details of the Target

General Information of Target

Target ID LDTP03199
Target Name Lutropin-choriogonadotropic hormone receptor (LHCGR)
Gene Name LHCGR
Gene ID 3973
Synonyms
LCGR; LGR2; LHRHR; Lutropin-choriogonadotropic hormone receptor; LH/CG-R; Luteinizing hormone receptor; LHR; LSH-R
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLP
VKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFI
NLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLK
LYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSY
GLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENF
SKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYD
FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDS
QTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRL
RHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFF
IICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLIT
VTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYT
SNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
Target Type
Successful
Target Bioclass
GPCR
Family
G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily
Subcellular location
Cell membrane
Function Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
TTD ID
T79473
Uniprot ID
P22888
DrugMap ID
TT2O4W9
Ensemble ID
ENST00000294954.12
HGNC ID
HGNC:6585
ChEMBL ID
CHEMBL1854

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.G358S .
HCC1187 SNV: p.D564N .
HCT116 SNV: p.E325K .
IGROV1 SNV: p.A538T .
JHH4 SNV: p.K143M .
KARPAS422 SNV: p.R88G .
L428 Substitution: p.L227M .
LOXIMVI SNV: p.L384P .
MDST8 SNV: p.V364I .
MEWO SNV: p.I541T .
NCIH1792 SNV: p.V311L .
NCIH2286 SNV: p.A49D .
SNGM SNV: p.K12Q; p.Q235H .
SNU245 SNV: p.R124Ter .
WM115 SNV: p.E206K .
WM2664 SNV: p.E206K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C4655(4.87)  LDD3410  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A-375 C4655(2.80)  LDD2255  [1]
 LDCM0023  KB03 A-375 C4655(5.25)  LDD2672  [1]
 LDCM0024  KB05 RPMI-7951 C4655(4.87)  LDD3410  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840