Details of the Target
General Information of Target
| Target ID | LDTP03195 | |||||
|---|---|---|---|---|---|---|
| Target Name | Arylacetamide deacetylase (AADAC) | |||||
| Gene Name | AADAC | |||||
| Gene ID | 13 | |||||
| Synonyms |
DAC; Arylacetamide deacetylase; EC 3.1.1.3 |
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| 3D Structure | ||||||
| Sequence |
MGRKSLYLLIVGILIAYYIYTPLPDNVEEPWRMMWINAHLKTIQNLATFVELLGLHHFMD
SFKVVGSFDEVPPTSDENVTVTETKFNNILVRVYVPKRKSEALRRGLFYIHGGGWCVGSA ALSGYDLLSRWTADRLDAVVVSTNYRLAPKYHFPIQFEDVYNALRWFLRKKVLAKYGVNP ERIGISGDSAGGNLAAAVTQQLLDDPDVKIKLKIQSLIYPALQPLDVDLPSYQENSNFLF LSKSLMVRFWSEYFTTDRSLEKAMLSRQHVPVESSHLFKFVNWSSLLPERFIKGHVYNNP NYGSSELAKKYPGFLDVRAAPLLADDNKLRGLPLTYVITCQYDLLRDDGLMYVTRLRNTG VQVTHNHVEDGFHGAFSFLGLKISHRLINQYIEWLKENL |
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| Target Bioclass |
Enzyme
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| Family |
'GDXG' lipolytic enzyme family
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| Subcellular location |
Endoplasmic reticulum membrane
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| Function |
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C340(1.65) | LDD3368 | [1] | |
Competitor(s) Related to This Target