Details of the Target

General Information of Target

Target ID LDTP03190
Target Name Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)
Gene Name SLC2A5
Gene ID 6518
Synonyms
GLUT5; Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEQQDQSMKEGRLTLVLALATLIAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGE
FMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSR
VATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIF
GLRNLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQKKDEAAAKKALQTLRGW
DSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYA
DQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLT
AALALQDTVSWMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHW
LSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTTIYIFLIVPETKAKTFIEINQIFTKMNK
VSEVYPEKEELKELPPVTSEQ
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
Subcellular location
Apical cell membrane
Function
Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of 2-deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.
Uniprot ID
P22732
Ensemble ID
ENST00000377414.7
HGNC ID
HGNC:11010
ChEMBL ID
CHEMBL5875

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 Deletion: p.N188TfsTer2 .
HCT116 SNV: p.E311D .
RKO SNV: p.A332S; p.T368I .
RVH421 SNV: p.E63K .
SKOV3 SNV: p.L279P .
SNGM SNV: p.N94D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C118(1.46)  LDD2182  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C118(1.27)  LDD2187  [1]
 LDCM0573  Fragment11 Ramos C118(0.69)  LDD2190  [1]
 LDCM0576  Fragment14 Ramos C118(1.17)  LDD2193  [1]
 LDCM0586  Fragment28 Ramos C118(3.38)  LDD2198  [1]
 LDCM0566  Fragment4 Ramos C118(1.89)  LDD2184  [1]
 LDCM0569  Fragment7 Ramos C118(1.67)  LDD2186  [1]
 LDCM0022  KB02 Ramos C118(1.46)  LDD2182  [1]
 LDCM0023  KB03 Ramos C118(1.72)  LDD2183  [1]
 LDCM0024  KB05 Ramos C118(1.06)  LDD2185  [1]

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578